The Sire and Dam, Rolo and Olive have an impressive set of clear DNA health tests as detailed below.

 

• DNA tested for Progressive Retinal Atrophy (prcd-PRA) – CLEAR

• DNA tested for Progressive Retinal Atrophy (rcd4-PRA LOPRA) – CLEAR

• DNA tested for Von Willebrand's Disease Type 1 (vWD-1) – CLEAR

• DNA tested for Degenerative Myelopathy (DM) – CLEAR

• DNA tested for Familial Nephropathy (FN) – CLEAR

• DNA tested for Hyperuricosuria / Urate Stones (HUU) – CLEAR

• DNA tested for Malignant Hyperthermia (MH) – CLEAR

• DNA tested for Macrothrombocytopenia (MTC-D) – CLEAR

• Hereditary Unaffected of AMS

 

 

The Rules of Hereditary Diseases in Dogs DNA - 

(You need to read this to understand why our puppies and any extensively health tested puppies are so precious, and to understand basically dogs inherit a disease, or pass it on to their offspring. )

 

Dogs are born in one of three categories. They can either be Clear of a hereditary disease and do not and will never carry it or be affected by it at any point in their lives, so the disease is not present in their DNA. Or they are a carrier, which means the disease is present in their DNA, but they will never be affected by it, but if bred to a dog who carries the same disease, or an affected dog, it will pass it on to its offspring. A dog can also be born affected with a hereditary disease. They will be affected by this disease at some point in their life, there is no escaping it.

If a Clear dog is mated to a Carrier bitch the puppies will mostly be clear, with a small percentage being carriers. If a Carrier Dog is mated to a carrier bitch, usually all of the puppies will be affected, sometimes one may escape being a carrier. An Affected dog mated with a clear bitch will produce carrier puppies.

To put it simply

Clear x Clear = Clear puppies

Clear x Carrier = Mostly Clear, a percentage may be carriers

Clear x Affected = Carrier puppies

Carrier x Carrier =  Affected puppies

Affected x Affected = Affected Puppies

 

Almost all inherited diseases set in either before 2 years of age or around 7- 8 years of age.

 

To put it blankly. Rolo has been scientifically DNA screened and tested for almost all (except AMS, which a Cocker Spaniel disease, so can't carry it anyway) As he is clear, NONE of his offspring will ever be affected. None. Even if he is mated to a girl who is affected by all the diseases above, non of her puppies, sired by Rolo, will ever inherit them. They MAY be carriers, but this means that they will never suffer themselves, only that you need to find a stud will DNA screenings if you ever breed.

 

Most puppies for sale at the moment have one or two health testings, imagine how many they new owners don't know about! Having security is invaluable to have a dog who will grow up and live to old age in happiness, an also to save huge vet bills for treatment of these diseases later or ealier in life.​

Unfortunately, most Cockapoo puppies for sale at the moment only have a father with PRA clear, so may not even be clear of this disease. Imagine how many DNA diseases that are not tested for that those puppies might have. As many DNA diseases show themselves at around 7 -8 years old, the father and/or mother may be affected by but the owners don't know it at the time of breeding.

They are then unknowingly passing mutilated genes on to their puppies.

 

DETAILS OF OLIVE AND ROLO'S HEALTH TESTS.

 

Progressive Retinal Atrophy (prcd-PRA)

PRA (Progressive Retinal Atrophy) is an inherited disease that is relevant to many dog breeds and comes in different forms. The prcd (Progressive Rod Cone Degeneration) form of PRA causes the cells in the retina to slowly deteriorate and over time the affected dog could potentially suffer from night blindness to complete blindness, however, some affected dogs may show mild signs of sight loss. The age which a dog shows symptoms of this disease can vary but usually a young adult dog may show symptoms that will over time deteriorate.

 

 

Breeds affected include American Cocker Spaniel, American Eskimo, Australian Cattle Dog, Australian Shepherd, Chesapeake Bay Retriever, Chinese Crested, English Cocker Spaniel, English Cockapoo, American Cockapoo, Entlebuch Mountain dog, Finnish Lapphund, Golden Retriever, Kuvasz, Labrador Retriever, Lapponian Herder, Miniature Poodle, Nova Scotia Duck Tolling Retriever, Portuguese Waterdog, Silky Terrier, Swedish Lapp Hund, Toy Poodle, Spanish Water Dog, Yorkshire Terrier, Dwarf Poodle, Norwegian Elkhound, Labradoodle, Australian Stumpy Tail Cattle Dog, Markiesje.

 

 

Progressive Retinal Atrophy (rcd4-PRA LOPRA)

PRA (Progressive Retinal Atrophy) is an inherited disease that is relevant to many dog breeds and comes in different forms. The Rod-Cone Dysplasia Type 4 rcd4 LOPRA form is also known as Late Onset PRA as this form may not typically result in vision loss until the dog is in its senior year 7-12 years of age, however, the age of onset varies.

 

Breeds affected include Australian cattle dog, Irish Setter, Miniature Poodle, Poodle, Toy Poodle, English Setter, Standard Poodle, Tibetan Terrier, Polish Lowland Sheepdog, Dwarf poodle, Irish Red and White Setter, Gordon Setter and Small Munsterlander.

 

 

Von Willebrand's Disease Type 1 (vWD-1)

Von Willebrand disease (vWD) is an inherited bleeding disorder in dogs which is caused by lack of von Willebrand factor which is a protein that helps with the blood clotting process. If a dog is affected by vWD the blood may not clot well and causes prolonged bleeding. The disorder can range from mild prolonged bleeding to life-threatening haemorrhages in some cases.

 

Breeds affected include Doberman, Manchester Terrier, Miniature Poodle, Poodle, Toy Poodle, Pembroke Welsh Corgi, German Pinscher, Bernese Mountain Dog, Standard Poodle, Drentsche Patrijschond, Coton de Tulear, Kerry Blue Terrier, Papillon, Stabyhound and Labradoodle.

 

 

 

Degenerative Myelopathy (DM)

Degenerative Myelopathy which is also known as Degenerative Radiculomyelopathy is a progressive disease of the spinal cord. The disease typically affects dogs at a later age between 7 to 14 years old. It tends to start with the loss of coordination in the hind limbs, muscle weakness, difficulty walking, balance problems and may lead to a leg being dragged or the dog becoming crippled as the disease progresses, which may happen over a few months to a few years.

 

Breeds affected include All Dog Breeds, American Eskimo, Chesapeake Bay Retriever, German Shepherd, Golden Retriever, Labrador Retriever, Nova Scotia Duck Tolling Retriever, Poodle, Sheltie, Pembroke Welsh Corgi, Cardigan Welsh Corgi, Bernese Mountain Dog, Boxer, Rhodesian Ridgeback, Kerry Blue Terrier, Wire Fox Terrier, Pug, Borzoi, Hovawart, Soft Coated Wheaten Terrier, Canaan Dog, All Cocker Spaniel breeds and Great Pyrenees.

 

 

Familial Nephropathy (FN)

Familial Nephropathy is a fatal kidney disease which can affect English Cocker Spaniels at a young age between 6 months and 2 years. This disease can progress at differing rates and also have a differing symptom but it is ultimately fatal.

 

Breed affected is English Cocker Spaniel.

 

 

 

Hyperuricosuria / Urate Stones (HUU)

Hyperuricosuria is also known as Urate Stones which is the elevated levels of uric acid in the urine. Dogs affected by this condition are prone to form stones in their bladders or sometimes their kidneys. This is extremely painful and often fatal.

 

Breeds affected include all dog breeds.

 

 

Malignant Hyperthermia (MH)

Malignant Hyperthermia which is also known as MH and sometimes referred to as canine stress syndrome. It’s triggered by exposure to anaesthetic agents including succinylcholine or volatile. It’s an inherited disorder of skeletal muscle characterized by hypercarbia, rhabdomyolysis, generalized skeletal muscle contracture, cardiac dysrhythmia, and renal failure. Possible symptoms can include muscle stiffness, rapid breathing, high temperature, seizures and dilated pupils. However specific interventions, including the use of the calcium release channel antagonist dantrolene, are efficacious in reversing signs of this canine syndrome.

 

Breeds affected include all dog breeds.

 

 

 

Macrothrombocytopenia (MTC-D)

Macrothrombocytopenia which is also referred to as MTC-D is an inherited blood disorder characterised by oversized platelets and a low platelet count. The name is derived from the words macro (large) and thrombocyte (platelets), cells that assist in the blood clotting function. It is important to note that these dogs may mistakenly be considered to have an underlying disease that results in thrombocytopenia, such as immune-mediated thrombocytopenia, tick-borne infection or a bone marrow disorder.

 

Breeds affected include Chihuahua, Labrador Retriever, Miniature Poodle, Poodle, Toy Poodle, Cocker Spaniel, Boxer, Standard Poodle, Jack Russell Terrier, Parson Russell Terrier, Dwarf Poodle, Cavalier King Charles Spaniel, Havanese, Shih Tzu, Bichon Frise and Maltese.

 

 

Acral Mutilation Syndrome (AMS)

 

Acral mutilation syndrome is a hereditary disease. AMS causes progressive degeneration and abnormal development of the sensory neurons in the spinal cord and in the peripheral nerves; which will cause the loss of pain sensation in the extremities. Single or multiple limbs can be affected by the disease. The hind legs are believed to be more severely affected.  Dogs with acral mutilation syndrome will chew, bite, lick and self-mutilate their distal extremities which may result in ulcers and fungal or bacterial infections. In severe cases, auto-amputation of digits, pads and claws can occur. Canines will continue to walk on mutilated feet without showing pain or lameness.  Motor skills, coordination, and reflexes will all appear normal. Most dogs are put down before 2 years old.

 

Breeds most affected Acral mutilation syndrome are the Cocker Spaniel, others also affected are the German Short-Haired Pointer, English Pointer and the Miniature Schnauzer.